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Psilocybin Overdose | Can I overdose on Psilocybin?

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Psilocybin, the active ingredient in magic mushrooms, is becoming increasingly popular as a potential treatment for mental health conditions like depression and anxiety. While the drug has been found to be relatively safe in small to moderate doses, there is still a concern about the possibility of psilocybin overdose. 

This article will explore what is known about the potential risks of taking too much psilocybin, as well as what to do in the event of an overdose.

What Does Psilocybin Do? 

Psilocybin is a psychedelic substance that is found in certain species of mushrooms. When consumed, it is broken down in the body to produce psilocin, which acts on serotonin receptors in the brain. This leads to changes in perception, mood, and thought. 

Psilocybin can cause hallucinations, an altered sense of time, and a feeling of euphoria. It has also been found to have therapeutic potential for certain mental health conditions such as depression and anxiety. 

Can you overdose on Psilocybin? 

Although it is considered difficult to overdose on psilocybin mushrooms, there is still a substantial risk of overdoing psilocybin. According to the available research, there are no reported cases of fatal overdose from psilocybin alone. However, there have been reported cases of severe adverse reactions, such as panic attacks and temporary paranoia, even at low doses.

Ingesting large amounts of psilocybin can cause more intense hallucinations, confusion, and agitation, and in some cases, these symptoms can be distressing and lead to dangerous behavior. Therefore, it is not recommended to consume high doses of psilocybin.

It is also important to note that consuming psilocybin mushrooms can be unpredictable, as their effects depend on the dose, the specific species of mushroom, the individual’s physiology, and the setting in which they are consumed. Therefore, it’s always recommended to consume them under the guidance of a trained professional or in a controlled setting.

 

Normal dosage vs. lethal dosage?

The normal dosage of psilocybin mushrooms varies depending on the specific species of mushroom, the method of ingestion, and the individual’s tolerance and sensitivity to the drug. Generally, a low to moderate dose is considered to be around 1 to 2.5 grams of dried mushrooms, while a high dose is considered to be around 3 grams or more.

A lethal dose of psilocybin is not well established, as there are no reported cases of fatal overdose from the drug alone. However, it is important to note that consuming large amounts of psilocybin can cause severe adverse reactions, such as panic attacks and temporary paranoia, even at low doses.

Symptoms of Psilocybin overdose?

The symptoms of a psilocybin overdose are not well understood, as there are no reported cases of fatal overdose from the drug alone. However, consuming large amounts of psilocybin can cause more intense hallucinations, confusion, and agitation, and in some cases, these symptoms can be distressing and lead to dangerous behavior.

Some possible symptoms of a psilocybin overdose include:

  • Intense hallucination
  • Confusion and disorientation
  • Agitation and paranoia
  • Nausea and vomiting
  • Increased blood pressure and heart rate
  • Tremors and muscle twitching
  • Seizures
  • Coma

If you or someone you know is experiencing severe adverse reactions after consuming psilocybin mushrooms, it is important to seek medical attention immediately.

It’s important to keep in mind that the symptoms of psilocybin overdose can vary depending on the dose, the specific species of mushroom, the individual’s psychiatry, and the setting in which they are consumed.

What to do in case of Psilocybin overdose?

If you or someone you know is experiencing severe adverse reactions after consuming psilocybin mushrooms, it is important to seek medical attention immediately. Call emergency services, such as 911, or go to the nearest emergency room.

When seeking medical attention, it is important to let the healthcare provider know that the individual has consumed psilocybin mushrooms, as this will help them provide the appropriate treatment.

The treatment for a psilocybin overdose will depend on the severity of the symptoms and will be provided on a case-by-case basis. Generally, supportive care, such as providing a safe and calm environment, monitoring vital signs, and administering benzodiazepines to manage agitation, is recommended.

It’s important to keep in mind that psilocybin is a Schedule I controlled substance, which means that its possession, use, and distribution are illegal in most countries. Therefore, seeking medical help may also involve the authorities, and it’s important, to be honest, and transparent about the situation.

Who is at risk of Psilocybin overdose? 

Psilocybin overdose is rare, but it can occur, especially in individuals who consume high doses (especially as a result of psilocybin withdrawal) or who have underlying health conditions such as liver or kidney disease, heart problems, or mental health disorders such as schizophrenia or bipolar disorder. 

Individuals with a history of substance abuse, those who use psilocybin in combination with other drugs or alcohol, and people who have a sensitivity or allergy to psilocybin are also at higher risk of an overdose. 

Additionally, individuals who have had previous adverse reactions to psilocybin should exercise caution and seek medical attention if they experience symptoms such as severe anxiety, agitation, or hallucinations.

Can Psilocybin interact with other drugs? 

Yes, psilocybin can interact with other drugs, including prescription medications and other substances such as alcohol and cannabis. Some of these interactions can enhance or amplify the effects of psilocybin, while others can decrease its effectiveness or cause adverse reactions. 

It’s important to inform your healthcare provider of any medications or substances you’re taking before using psilocybin, as some interactions can be dangerous or even life-threatening. 

Additionally, combining psilocybin with other substances can increase the risk of an overdose and make it more difficult to predict the effects and consequences of the combination.

How is Psilocybin overdose treated? 

The treatment for psilocybin overdose depends on the severity of the symptoms and may vary from person to person. In mild cases, the symptoms may resolve on their own with time and support from friends or family. In more severe cases, medical attention may be required.

In a hospital setting, treatment may involve providing supportive care such as monitoring vital signs, providing fluids, and controlling symptoms such as agitation or anxiety with medications. In some cases, activated charcoal may be used to reduce the absorption of the psilocybin in the body, and in severe cases, medication to control seizures or treat hallucinations may be necessary.

It’s important to seek medical attention immediately if you suspect an overdose, as psilocybin can cause unpredictable and potentially dangerous side effects, especially when combined with other drugs or substances.

After the symptoms of overdose have subsided, it is important to seek treatment for psilocybin addiction to cut down the risk of another possible overdose.

Final thoughts on Psilocybin overdose

In conclusion, while psilocybin mushrooms are generally considered safe when used responsibly, it is possible to overdose on psilocybin. Symptoms of psilocybin overdose can range from mild to severe and may include confusion, paranoia, and even death in rare cases. 

It is important for individuals considering using psilocybin to educate themselves on safe dosing practices and to only use the substance in a controlled and supportive environment. If an overdose is suspected, seeking medical attention immediately is crucial. 

Warren

Warren Phillips

Warren is a Licensed Master Social Worker, who specializes in substance abuse and mental health treatment. Clinically, Warren has developed a therapeutic skillset that utilizes a strengths-based perspective, Twelve Step philosophies, Cognitive Behavioral Therapy and Motivational Interviewing.

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Located on the historic peninsula of Charleston, South Carolina, Lantana Recovery takes a modern approach to Substance Use Disorder treatment, offering intensive clinical care while also immersing our clients in local Charleston culture.